Run PopPhy-CNN

PopPhy-CNN source code examples

Example Cirrhosis abundance file download
Example Cirrhosis labels file download

T-BAS examples

Example switchgrass fungi T-BAS assignments file download
Example switchgrass fungi counts file download
Example switchgrass fungi metadata file download

The abundance file is a sample counts table with qiime formatted names. If this is not available then drop the T‑BAS file in the drop box and a sample counts file in the abundance.tsv box.

If the labels file is available as in the Cirrhosis example, then use that. If not then use a samples metadata file with a column named popphy_label that assigns classes to samples

Note that underscores are not allowed in the sample names.

If the names in the first column of the counts table are ASVs, then check this box. If the names in the first column are sample ids then do not check this box.

This option removes submitted ASVs by kingdom assignmnent. It makes the program run faster if the submission includes multiple kingdoms.

To use a T-BAS assignments file to create inputs the counts table row and column names must match the assignments file row names and labelled sample attributes file row names, depending on the format of the counts table.

Drop assignments file (optional)

Drop counts table

Drop labels file

Options help

Options help (L2Lambda)

If your data is already normalized, a good starting point for the L2 regularization rate (also called "lambda" or "weight decay") is usually a small value like 0.001 or 0.01. Since normalization helps prevent features from dominating due to scale differences, you can apply a slightly stronger regularization penalty compared to unnormalized data.
To facilitate combining treescores files from multiple runs add a meaningful annotation.
uploading files (please wait)

Citation

Reiman D, Metwally AA, Sun J, Dai Y. PopPhy-CNN: A Phylogenetic Tree Embedded Architecture for Convolutional Neural Networks to Predict Host Phenotype From Metagenomic Data. IEEE J Biomed Health Inform. 2020 Oct;24(10):2993-3001. doi: 10.1109/JBHI.2020.2993761. Epub 2020 May 11. PMID: 32396115.

https://github.com/YDaiLab/PopPhy-CNN

For Pylum to Kingdom. Catalogue of Life